COVID‐19 Vaccination and Gout Flare Risk in Patients With Infrequent or Frequent Flares: A Prospective Cohort Study
Authors' conclusion
COVID-19 vaccination was associated with increased early gout flares only in patients with previously infrequent flares.
Study context
- Population
- COVID-19 vaccine-naive gout patients managed with ULT between February and June 2021248 received two-dose vaccination
- Participants
- 530 patients
- Exposure
- COVID-19 vaccination vs no vaccination, in patients with infrequent or frequent gout flares
- Infrequent flaresn = 308
- Frequent flaresn = 222
- Outcome
- Cumulative gout flare incidence
- Follow-up
- 12 weeks
Methodological detailsvoluntary vaccination, multivariable analyses
- Voluntary vaccination
- Multivariable analyses
Main finding
As reported in the abstract
Cumulative flare incidence, vaccinated vs unvaccinated
Infrequent flares: vaccinated vs unvaccinated
26.1% vs 10.8%
P = 0.001
Frequent flares: vaccinated vs unvaccinated
60.4% vs 65.5%
P = 0.428
Observational data: associations, not effects.
Further findings
Independent risk factors for flare, infrequent flares (multivariable)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Vaccination | 2.82 (1.50–5.30) | P = 0.001 | |
| Flare in the preceding year | 1.95 (1.03–3.71) | P = 0.04 | |
| BMI | 1.09 (1.01–1.19) | P = 0.03 | |
| 0.20.5125Odds ratio (log scale) |
Independent risk factor for flare, frequent flares (multivariable)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Baseline serum urate (mg/dl) | 1.23 (1.05–1.45) | P = 0.012 | |
| 0.512Odds ratio (log scale) |
Flare incidence in final 4 weeks of observation, infrequent flares: vaccinated vs unvaccinated
- Decreased significantly only in the vaccinated infrequent flare group
- 4.3% vs 12.0%, P = 0.017
Original publication
COVID‐19 Vaccination and Gout Flare Risk in Patients With Infrequent or Frequent Flares: A Prospective Cohort Study. Arthritis Care Res (Hoboken). Published 9 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →