Correlation of serum citrullinated histone H3 levels with disease activity in patients with rheumatoid arthritis
Authors' conclusion
CitH3 is significantly associated with disease activity and could serve as a useful candidate biomarker to assess disease activity in patients with RA.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and healthy controls151 RA patients · 56 healthy controls
- Participants
- 69 / 32 / 20 / 30 / 56
- Exposure
- Serum CitH3 levels across RA disease activity categories and healthy controls
- Highly active RAn = 69
- Moderately active RAn = 32
- Mildly active RAn = 20
- RA in remissionn = 30
- Healthy controlsn = 56reference
- Outcome
- Discriminant capacity of serum CitH3 between highly/moderately active RA and RA in remission/mild activity (ROC)
Methodological detailsROC curve analysis, machine-learning predictive model
- ROC curve analysis
- Machine-learning predictive model
Main finding
As reported in the abstract
AUC of CitH3 for discriminating RA activity levels
AUC
- Highly active RA vs Mildly active RA
- 0.825
- Highly active RA vs RA in remission
- 0.840
- Moderately active RA vs Mildly active RA
- 0.789
- Moderately active RA vs RA in remission
- 0.829
Observational data: associations, not effects.
Further findings
Correlations of serum CitH3 with disease variables
- Positively associated with DAS28-ESR, ESR, CRP, RF, WBC, RDW, PLT, N and N%
- Negatively associated with haemoglobin, lymphocyte percentage and thyroid-stimulating hormone
Machine-learning predictive model
- Optimal predictive model selected and had high performance
Original publication
Correlation of serum citrullinated histone H3 levels with disease activity in patients with rheumatoid arthritis. Clin Exp Rheumatol. Published 15 August 2022. doi:10.
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