Systemic sclerosis & Raynaud's
Construct validity and reliability of the Assessment of Systemic Sclerosis-Associated Raynaud’s Phenomenon (ASRAP) questionnaire
Authors' conclusion
ASRAP and ASRAP-SF questionnaires are valid and reliable novel PRO instruments for assessing the severity and impact of SSc-RP.
Study context
- Population
- SSc subjects with SSc-associated RP
- Participants
- 420 subjects
- Comparison
- ASRAP vs ASRAP-SF
- Outcome
- Construct validity and reliability of a novel patient-reported outcome (PRO) instrument for assessing the severity and impact of RP in SSc
Methodological detailsinternational, multicentre, Repeatability evaluated at 1 week, Anchor-based statements of health status for ASRAP thresholds of meaning
- International
- Multicentre
- Repeatability evaluated at 1 week
- Anchor-based statements of health status for ASRAP thresholds of meaning
Performance
As reported in the abstract
Construct validity and reliability
- Correlation of ASRAP (and ASRAP-SF) with RP visual analogue scale (VAS) and Scleroderma HAQ RP VAS (rho range)
- 0.648-0.727, P < 0.001
- Correlation with diary-based SSc-RP attack frequency and duration (rho range)
- 0.258-0.504, P < 0.001
- Correlation with instruments for disability, hand function, pain and global health assessment (rho range)
- 0.427-0.575, P < 0.001
- Significantly higher ASRAP scores in smokers, active digital ulceration (DU), previous history of DU and calcinosis
- P < 0.05 for all comparisons
- Repeatability at 1 week among stable SSc-RP symptoms, intra-class coefficients
- 0.891 and 0.848, P < 0.001
- Patient-acceptable symptom state threshold, ASRAP
- 45.34
- Patient-acceptable symptom state threshold, ASRAP-SF
- 45.77
- Preliminary Minimally Important Clinical Difference threshold
- 4.17 (95% CI 0.53, 7.81, P = 0.029)
Original publication
Construct validity and reliability of the Assessment of Systemic Sclerosis-Associated Raynaud’s Phenomenon (ASRAP) questionnaire. Rheumatology (Oxford). Published 22 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →