Lupus & antiphospholipid syndrome
Considering belimumab during pregnancy: A more viable option over time
Authors' conclusion
Belimumab may be an option for pregnant women with difficult-to-control lupus.
Study context
- Population
- Pregnant women with lupus
- Participants
- 12 women16 pregnancies
- Outcome
- Pregnancy outcomes with belimumab:
- Own cohort
- 8 pregnancies
Methodological detailsdescriptive, MEDLINE and EMBASE searched, plus secondary hand search; studies evaluated descriptively
- Descriptive
- MEDLINE and EMBASE searched, plus secondary hand search; studies evaluated descriptively
Main finding
As reported in the abstract
- Miscarriage
- 1
- Elective termination
- 1
- Live foetuses (including two live twins)
- 7
- Type I intrauterine growth retardation
- 1
- Preterm pregnancy due to PPROM
- 1
- Mild lupus flare
- 1
- Pre-eclampsia, gestational diabetes mellitus or hypertension
- 0
- Congenital anomalies
- 0
Observational data: associations, not effects.
Further findings
Literature review: 10 case reports and case series, 5 registries (39 reported cases, 41 pregnancies)
- PPROM
- 5
- Pre-eclampsia
- 4
- Eclampsia
- 1
- New-borns with low birth weight
- 19
- Malformations
- 0
- All women made full recoveries
- Registries: no increased risk of birth defects or pregnancy loss; higher risk of neonatal infections
Original publication
Considering belimumab during pregnancy: A more viable option over time. Lupus. Published 9 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →