Comparison of radiological and functional outcomes of conservative treatment with teriparatide and denosumab in thoracolumbar osteoporotic vertebral fracture
Main finding · Fracture union with paravertebral bone bridge formation (FUPB)Result — go to the resultOdds ratio 4.486Authors' conclusion
Teriparatide and denosumab, despite of their different pharmacological mechanisms, showed similar radiological deformation and functional outcomes in the conservative treatment of TL-OVF. However, teriparatide showed a significantly higher incidence of fracture union with paravertebral bone bridge formation.
Study context
- Population
- Women (mean age 74.69 ± 7.66 years) with thoracolumbar osteoporotic vertebral fracture without neurological deficits, treated conservatively
- Participants
- 78 women
- Exposure
- Teriparatide vs denosumab, conservative treatment for 6 months
- Tn = 34
- Dn = 44reference
- Outcome
- Fracture union with paravertebral bone bridge formation (FUPB)
- Follow-up
- 6 months
Methodological detailsmultivariable logistic analysis
- Multivariable logistic analysis
Main finding
As reported in the abstract
Odds ratio
4.486
P = 0.012
Events by group
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Radiological deformation (kyphotic angle, segmental vertebral kyphotic angle, compression ratio) and functional outcomes (VAS, ODI) · 0, 3 and 6 months | P > 0.05 |
Radiological deformation (kyphotic angle, segmental vertebral kyphotic angle, compression ratio) and functional outcomes (visual analog scale (VAS), Oswestry Disability Index (ODI)) · 0, 3 and 6 months
- No significant differences between the two groups
Original publication
Comparison of radiological and functional outcomes of conservative treatment with teriparatide and denosumab in thoracolumbar osteoporotic vertebral fracture. Osteoporos Int. Published 23 January 2024. doi:10.
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