Conservative treatments for non-surgically managed osteoporotic vertebral compression fractures: a network meta-analysis of long-term pain and quality of life
Authors' conclusion
Teriparatide is the most effective non-surgical intervention for long-term pain and QoL outcomes in OVCF patients.
Study context
- Population
- Adults (≥ 50 years) with radiographically confirmed osteoporotic vertebral compression fractures12 articles
- Participants
- 1,512 adults
- Comparison
- Conservative interventions for osteoporotic vertebral compression fractures (OVCFs)
- Outcome
- Long-term pain relief and QoL improvement
- Follow-up
- ≥ 6 months
Methodological detailsPRISMA-NMA, frequentist random-effects model
- PRISMA-NMA
- Frequentist random-effects model
Pooled result
As reported in the abstract
SMD
- 1.75
95% CI - 3.10 to - 0.39
Teriparatide · pain reduction
SMD
+ 3.90
95% CI 2.33–5.47
Teriparatide · quality of life (QoL) improvement
SMD
+ 3.47
Denosumab · QoL improvement; moderate benefit
Original publication
Conservative treatments for non-surgically managed osteoporotic vertebral compression fractures: a network meta-analysis of long-term pain and quality of life. Osteoporos Int. Published 13 January 2026. doi:10.
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