Cohort study of serological biomarkers for interstitial lung disease in patients with rheumatoid arthritis
Authors' conclusion
CA15-3 was the most significant biomarker for ILD detection in RA patients with stable low disease activity, closely followed by MMP-7.
Study context
- Population
- Patients from the Early Rheumatoid Arthritis Program evaluated for interstitial lung disease (ILD) with high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs) (SCAPIS protocol)2 with prior ILD diagnosis
- Participants
- 55 patients
- Exposure
- Rheumatoid arthritis (RA) with ILD vs RA without ILD
- Outcome
- Eight serological biomarkers for RA-ILD detection
Methodological detailsfive ILD definition models (A = HRCT; B = PFTs; C = A plus B; D = C plus symptoms; E = D plus inhalations)
- Five ILD definition models (A = HRCT; B = PFTs; C = A plus B; D = C plus symptoms; E = D plus inhalations)
Main finding
As reported in the abstract
Biomarkers differentiating RA with and without ILD
- CA15-3 and MMP-7 differentiated between RA with and without ILD
- all p < 0.05
Observational data: associations, not effects.
Further findings
ILD prevalence
- Over one-third fulfilled the ILD criteria
Pearson correlations of MIP-1β and YKL-40 with disease activity markers
- MIP-1β with DAS28
- 0.3
- YKL-40 with DAS28
- 0.4
- MIP-1β with ESR
- 0.3
- YKL-40 with ESR
- 0.4
- MIP-1β with CRP
- 0.4
- All p < 0.05
Pearson correlation of CA15-3 with RF and ACPA
- CA15-3 with RF and ACPA
- 0.3
- Both p = 0.03
Original publication
Cohort study of serological biomarkers for interstitial lung disease in patients with rheumatoid arthritis. Scand J Rheumatol. Published 25 October 2024. doi:10.
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