Effectiveness of JAK Inhibitors Compared With Biologic Disease‐Modifying Antirheumatic Drugs on Pain Reduction in Rheumatoid Arthritis: Results From a Nationwide Swedish Cohort Study
Main finding · Change in pain (VAS 0-100 mm), adjustedResult — go to the resultAdjusted mean additional decrease 4.0 mm 95% CI 1.6–6.3Authors' conclusion
JAKis had a slightly better effect on pain outcomes at 3 and 12 months compared with TNFis, with significantly greater differences in patients previously treated with at least two bDMARDs. The effect of JAKis on pain reduction was at least similar to that of non-TNFi bDMARDs.
Study context
- Population
- Patients with RA starting a JAKi or bDMARD in 2017 to 2019, Swedish national registers
- Participants
- 1,827 / 6,422 / 887 / 1,102 / 1,149
- Exposure
- JAKi vs biologic disease-modifying antirheumatic drugs (bDMARDs)
- JAKin = 1,827
- Tumor necrosis factor inhibitor (TNFi)n = 6,422reference
- IL-6 inhibitorn = 887
- Abataceptn = 1,102
- Rituximabn = 1,149
- Outcome
- Change in pain (VAS 0-100 mm) from baseline
- Follow-up
- 3 months
Methodological detailsnationwide, linked Swedish national registers, multivariable linear regression
- Nationwide
- Linked Swedish national registers
- Multivariable linear regression
Main finding
Change in pain (VAS 0-100 mm), adjusted
Adjusted mean additional decrease
4.0 mm
95% CI 1.6–6.3
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted change contrast (percentage points) (95% CI) | |
|---|---|---|
| Low pain (VAS pain <20) in patients previously treated with at least two bDMARDs (subgroup) · 12 monthsJAKivs TNFi | 5.3 (1.0–9.6) | |
| −50510Difference, percentage points (linear scale) |
Remaining on initial treatment with low pain (VAS pain <20) · 12 months
- More patients achieved low pain on JAK inhibitors (JAKis) compared with TNFis
Original publication
Effectiveness of JAK Inhibitors Compared With Biologic Disease‐Modifying Antirheumatic Drugs on Pain Reduction in Rheumatoid Arthritis: Results From a Nationwide Swedish Cohort Study. Arthritis Rheumatol. Published 25 October 2024. doi:10.
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