Risk profiles for rheumatoid arthritis-associated interstitial lung disease in a cohort of patients with five-year follow-up
Authors' conclusion
The three algorithms identified approximately one-third of the cohort as being at increased risk of ILD.
Study context
- Population
- Patients with rheumatoid arthritis (RA) followed for 5 years after RA diagnosis with pulmonary function tests, dyspnoea score and pulmonary imaging
- Participants
- 115 patients
- Exposure
- Four-factor risk score vs ILD screening criteria vs risk score for detection of subclinical RA-ILD
- Outcome
- Proportion of patients assigned a high-risk profile by each model
Methodological details5-year follow-up, comparison of three screening models
- 5-year follow-up
- Comparison of three screening models
Main finding
As reported in the abstract
Proportion of cohort assigned high (increased) risk of ILD
| Group | Value | Intermediate risk | Highest risk group |
|---|---|---|---|
| Four-factor risk score | 22% | ||
| ILD screening criteria | 37% | 34% (39/115) | |
| Risk score for subclinical RA-ILD | 44% | 7% |
Value
Four-factor risk score22%
ILD screening criteria37%
Risk score for subclinical RA-ILD44%
Intermediate risk
Four-factor risk score— not stated in the abstract
ILD screening criteria34% (39/115)
Risk score for subclinical RA-ILD— not stated in the abstract
Highest risk group
Four-factor risk score— not stated in the abstract
ILD screening criteria— not stated in the abstract
Risk score for subclinical RA-ILD7%
- Agreement between high-risk groups in the two clinical ILD screening models: moderate (kappa)
- 0.43
Observational data: associations, not effects.
Further findings
- Patients with clinical or subclinical ILD, all identified as high risk in the two clinical models
- 3
Original publication
Risk profiles for rheumatoid arthritis-associated interstitial lung disease in a cohort of patients with five-year follow-up. Scand J Rheumatol. Published 24 October 2024. doi:10.
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