Single‐Cell Analysis Reveals Peripheral Helper T Cells in Rheumatoid Arthritis–Related Interstitial Lung Disease
Authors' conclusion
We report a detailed transcriptomic analysis of the epithelial and immune cells in RA-ILD lungs and include a cross-tissue comparison that demonstrates organ-specific variations in the characteristics of Tph cells.
Study context
- Population
- Lung explants (epithelial and immune cells) from controls, patients with non-RA CTD-ILD and patients with RA-ILD; immunofluorescence on lung sections incl. idiopathic pulmonary fibrosis184,814 cells profiled
- Comparison
- RA-ILD vs non-RA CTD-ILD vs controls
- Controlsn = fourreference
- Non-RA CTD-ILDn = three
- RA-ILDn = five
- Outcome
- Cellular and transcriptomic landscape of epithelial and immune cells in RA-ILD
Methodological detailssingle-cell RNA sequencing, integrative analysis with publicly available synovial T cell data, confirmatory immunofluorescence staining, Immunofluorescence staining on lung sections from four controls, nine RA-ILD, eight non-RA CTD-ILD and six idiopathic pulmonary fibrosis patients
- Single-cell RNA sequencing
- Integrative analysis with publicly available synovial T cell data
- Confirmatory immunofluorescence staining
- Immunofluorescence staining on lung sections from four controls, nine RA-ILD, eight non-RA CTD-ILD and six idiopathic pulmonary fibrosis patients
Main finding
As reported in the abstract
Cell clusters identified
18
Original publication
Single‐Cell Analysis Reveals Peripheral Helper T Cells in Rheumatoid Arthritis–Related Interstitial Lung Disease. Arthritis Rheumatol. Published 17 February 2026. doi:10.
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