Clonal T cell populations scarcely impair patients with rheumatic diseases: a prospective long-term follow up study
Authors' conclusion
Clonal T cell populations in patients with rheumatic diseases are common, but are rarely harmful.
Study context
- Population
- Patients with RA, SpA or GCA and clonal T cell populationsfollowed up to 7.6 years
- Participants
- 28 patients
Methodological detailslong-term follow-up
- Long-term follow-up
Main finding
As reported in the abstract
- Clonal T cell populations mostly persisted over time
- Tumor burden decreased in the long term
Observational data: associations, not effects.
Further findings
Cytokine secretion in stimulated T cell cultures, RA subgroup with vs without clonal T cells
- Did not differ
Safety
- Autoimmune neutropenias
- 10.7%
- Severe infections or cytopenias were rare
Original publication
Clonal T cell populations scarcely impair patients with rheumatic diseases: a prospective long-term follow up study. Arthritis Res Ther. Published 11 December 2024. doi:10.
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