Autoinflammatory & rare systemic diseases
Clinical phenotypes of sarcoidosis using cluster analysis: a Spanish population-based cohort study
Authors' conclusion
Five phenotypes with different clinical and prognostic characteristics are proposed in our study.
Study context
- Population
- Sarcoidosis patients diagnosed and followed up 1999–2019 in a tertiary hospital in Northern Spain
- Participants
- 342 patients
- Exposure
- Five clinical clusters of sarcoidosis
- Outcome
- Identification of clinical phenotypes by cluster analysis
Methodological detailsmodel-based cluster analysis on 19 clinical variables, single-centre (tertiary hospital)
- Model-based cluster analysis on 19 clinical variables
- Single-centre (tertiary hospital)
Main finding
As reported in the abstract
| Outcome | Values |
|---|---|
| Values | C1 16.1% · lung involvement 100% · C2 14.3% · lung involvement 55.1% · extrapulmonary involvement 96.4% · C3 24.3% · extrapulmonary involvement 98.0% · C4 5.0% · lung involvement 100% · C5 40.4% |
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| FEV1 percent predicted | C1 102.0 ± 22.9 % predicted · C3 102.3 ± 17.6 % predicted · C4 105.8 ± 20.8 % predicted · C5 90.5 ± 21.8 % predicted |
| FVC percent predicted | C3 108.1 ± 18.0 % predicted · C4 111.5 ± 21.7 % predicted · C5 96.6 ± 18.9 % predicted |
| Chronicity rate | C1 9.1% · C3 31.3% · C4 0% · C5 32.6% |
FEV1 percent predicted
- Significantly lower FEV1 % predicted in C5 vs C1, C3 and C4
FVC percent predicted
- C5 had lower FVC % predicted than others (others ranging from C3 to C4 values)
Chronicity rate
- Wasfi severity score also higher in C3 and C5 than C1 and C4
Systemic GC and non-corticosteroid immunosuppressant prescription
- Higher in clusters 1, 3 and 5
Original publication
Clinical phenotypes of sarcoidosis using cluster analysis: a Spanish population-based cohort study. Clin Exp Rheumatol. Published 10 January 2024. doi:10.
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