Clinical features and survival analysis of 40 cases of anti-MDA5 antibody-positive dermatomyositis complicated with interstitial lung disease
Authors' conclusion
Anti-MDA5 antibody + DM is prone to interstitial lung disease, poor prognosis, and high mortality.
Study context
- Population
- Anti-MDA5 antibody-positive DM with ILD, Second Affiliated Hospital of Xi'an Jiaotong University, September 2018 to May 2022
- Participants
- 40 participants
- Exposure
- Survival vs non-survival during hospitalization
- Outcome
- Overall survival (OS) during hospitalization (prognostic factors; nomogram predicting 1-, 2- and 3-month OS)
Methodological detailssingle-centre, multivariate Cox regression, nomogram internally validated (C-index, calibration curves, 1000 bootstrap resamples), time-dependent decision curve analysis
- Single-centre
- Multivariate Cox regression
- Nomogram internally validated (C-index, calibration curves, 1000 bootstrap resamples)
- Time-dependent decision curve analysis
Main finding
As reported in the abstract
Risk factors for poor prognosis (multivariate Cox regression)
- Increased nonspecific interstitial pneumonia (NSIP) on high-resolution computed tomography (HRCT) and ALT, LDH, CEA, CRP were risk factors for poor prognosis
- P < 0.05
Observational data: associations, not effects.
Further findings
Differences between survival and non-survival groups
- Significant differences in age, oxygenation index, extent of lung lesions, diffuse alveolar damage (DAD) and NSIP, and serum LDH, GLU, CEA, ferritin, CRP
- P < 0.05
Survival by ALT, AST, LDH, CEA and CRP cutoff values (Kaplan-Meier (K-M))
- Survival curves differed by cutoff grouping
- P < 0.05
Nomogram clinical value (decision curve analysis (DCA))
- Nomogram yielded a higher net benefit than single prognostic factors; cutoff value grouping model showed better practical application value
Original publication
Clinical features and survival analysis of 40 cases of anti-MDA5 antibody-positive dermatomyositis complicated with interstitial lung disease. Arthritis Res Ther. Published 13 February 2025. doi:10.
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