Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease
Authors' conclusion
A high ANA titer in the absence of an AI disease was associated with increased risk of liver disorders and related risk factors and complications.
Study context
- Population
- Individuals without autoimmune disease who had an ANA test, Vanderbilt University Medical Center electronic medical recordHigh titer (HT) 3.1%, low titer (LT) 12.3%, negative (NG) 84.6%
- Participants
- 28,781 individuals
- Comparison
- High ANA titer vs low titer and negative ANA in individuals without autoimmune disease
- Outcome
- Prevalence of diagnoses recorded within 90 days of the ANA test
- Follow-up
- Within 90 days of the ANA test
Methodological detailsphenome-wide association study, de-identified electronic medical record, adjusted for age at ANA testing, sex, median body mass index (BMI) and reported race, significance threshold P <5 × 10-5
- Phenome-wide association study
- De-identified electronic medical record
- Adjusted for age at ANA testing, sex, median BMI and reported race
- Significance threshold P <5 × 10-5
Main finding
As reported in the abstract
Clinical diagnoses with increased risk in HT
Clinical diagnoses with increased risk, HT vs LT
46
Clinical diagnoses with increased risk, HT vs NG
67
Observational data: associations, not effects.
Further findings
Baseline characteristics among groups
- BMI similar among groups
- P = 0.345
- HT individuals older
- P = 3.9 × 10-73
Original publication
Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease. Arthritis Care Res (Hoboken). Published 20 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →