The clinical characteristics of subcutaneous and mediastinal emphysema in anti-melanoma differentiation-associated 5 positive dermatomyositis associated with interstitial lung disease
Authors' conclusion
We found that SE/ME is not uncommon in anti-MDA5-positive DM-ILD and is an important factor associated with poor patient prognosis. The occurrence of SE/ME is correlated with high levels of serum ferritin and is not related to anti-Ro-52 antibodies.
Study context
- Population
- Anti-MDA5-positive DM-ILD patients admitted to the authors' hospital
- Participants
- 117 patients
- Outcome
- Incidence and clinical characteristics of SE/ME
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Incidence of SE/ME in anti-MDA5-positive DM-ILD
- Incidence of SE/mediastinal emphysema (ME)
- 11.1%
- Significantly higher than in ASyS
- p<0.01
Observational data: associations, not effects.
Further findings
Mortality, SE/ME vs no SE/ME
- Mortality significantly higher with SE/ME than without
- P = 0.0022
SE/ME by anti-Ro-52 status
- No statistically significant difference, anti-Ro-52 positive vs negative
- P = 0.18
SE/ME by serum ferritin
- Higher likelihood with ferritin 1000–1500 ng/ml vs <500 ng/ml
- P < 0.01
Timing and positive pressure ventilation among 13 patients with SE/ME
- Developed SE/ME within 1 month of diagnosis
- six (46.2%)
- Positive pressure ventilation before SE/ME onset
- 53.8%
Original publication
The clinical characteristics of subcutaneous and mediastinal emphysema in anti-melanoma differentiation-associated 5 positive dermatomyositis associated with interstitial lung disease. Clin Exp Rheumatol. Published 11 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →