In inflammatory myopathies, dropped head/bent spine syndrome is associated with scleromyositis: an international case–control study
An erratum to this article was published (RMD Open, Sep 2023 ↗)
Authors' conclusion
In IM patients, DH/BS is a marker of severity and is associated with SSc (scleromyositis).
Study context
- Population
- Patients with inflammatory myopathies reported by practitioners from five inflammatory myopathies (IM) networks
- Participants
- 49 vs 98
- Comparison
- IM patients with DH/BS vs IM patients without DH/BS
- DH/BS-IMn = 49
- Control-IMn = 98reference
- Outcome
- Features associated with DH/BS in IM
Methodological detailsinternational, multicentre (five IM networks), controls randomly selected in each centre at a ratio of 2 to 1
- International
- Multicentre (five IM networks)
- Controls randomly selected in each centre at a ratio of 2 to 1
Main finding
As reported in the abstract
- DH/BS-IM
- Fulfilment of ACR/EULAR systemic sclerosis (SSc) criteria 40.8% vs 5.1%; P < 0.0001
- DH/BS-IM
- Age 65 years vs 53 years; P < 0.0001
- DH/BS-IM
- Delay to IM diagnosis 6 months vs 3 months; P = 0.009
- DH/BS-IM
- Weakness prevailing in upper limbs 42.9% vs 15.3%; P ≤ 0.0005
- DH/BS-IM
- Dysphagia 57.1% vs 25.5%; P ≤ 0.0005
- DH/BS-IM
- Muscle atrophy 65.3% vs 34.7%; P ≤ 0.0005
- DH/BS-IM
- Weight loss 61.2% vs 23.5%; P ≤ 0.0005
- DH/BS-IM
- Loss of ability to walk 24.5% vs 5.1%; P ≤ 0.0005
- DH/BS-IM
- Received IV immunoglobulins 65.3% vs 34.7%; P = 0.0004
- Distribution of the myopathy, its severity and its association with SSc were independently associated with DH/BS
- P < 0.05
Further findings
- Loss of walking ability independently associated with survival
- P < 0.05
- Mortality was higher in the DH/BS-IM patients
Original publication
In inflammatory myopathies, dropped head/bent spine syndrome is associated with scleromyositis: an international case–control study. RMD Open. Published 4 September 2023. doi:10.
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