Vasculitis & polymyalgia rheumatica
Clinical characteristics and treatment of infantile Takayasu arteritis in the Chinese Han population: a single-center study
Authors' conclusion
ITA is primarily characterized by fever and hypertension, along with elevated inflammatory biomarkers.
Study context
- Population
- Chinese Han infants diagnosed with infantile Takayasu arteritis (TA)
- Participants
- 18 infants
- Exposure
- Infliximab vs tocilizumab
- Infliximabn = 10
- Tocilizumabn = 8
- Outcome
- Clinical characteristics of infantile TA
- Follow-up
- Initial diagnosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Age of onset, days (average ± SD)
- 85.06 ± 54.64
- Fever
- 77.78%
- Hypertension
- 55.56%
- Kerr score (average)
- 3.28 ± 0.67
- Arterial involvement scores (AIS) (average)
- 10.67 ± 4.30
- Coronary artery involvement
- 72.22%
- Abdominal aorta involvement
- 72.22%
- Arterial wall thickening
- 100%
- Initially diagnosed with bacterial infections
- All patients
- Empirically diagnosed with Kawasaki disease
- 16
Observational data: associations, not effects.
Further findings
AIS and Kerr scores vs initial values · 6 months post-treatment
- AIS significant improvement (t = 2.469)
- P = 0.019
- Kerr score significant improvement (t = 12.369)
- P = 0.000
Tocilizumab vs infliximab
- No significant differences between the tocilizumab and infliximab treatment groups
Deaths · 12-month follow-up
- No deaths occurred
Original publication
Clinical characteristics and treatment of infantile Takayasu arteritis in the Chinese Han population: a single-center study. Pediatr Rheumatol Online J. Published 10 June 2025. doi:10.
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