Vasculitis & polymyalgia rheumatica
Clinical association of health-related quality of life and mortality in an antineutrophil cytoplasmic antibody-associated vasculitis cohort
Main finding · All-cause mortality per one-unit decrease in SF-36 PCS (multivariable Cox)Result — go to the resultHazard ratio 1.030 95% CI 1.007–1.052Authors' conclusion
Poor baseline physical functioning associated with premature death in patients with MPA and GPA.
Study context
- Population
- Patients with antibody-associated vasculitis (AAV) assessed for health-related quality of life (HRQoL) at initial diagnosis using SF-3621 (11.1%) died
- Participants
- 189 patients
- Exposure
- Lower vs higher baseline SF-36 physical component summary (PCS) and mental component summary (MCS) scores and all-cause mortality
- Outcome
- All-cause mortality
Methodological detailsmultivariable Cox proportional hazards model, inverse probability of treatment weighting (IPTW)
- Multivariable Cox proportional hazards model
- Inverse probability of treatment weighting (IPTW)
Main finding
As reported in the abstract
All-cause mortality per one-unit decrease in SF-36 PCS (multivariable Cox)
Hazard ratio
1.030
95% CI 1.007–1.052
P = 0.041
SF-36 PCS, per one-unit decrease
HR 1.030 (95% CI 1.007–1.052); P = 0.041
Per one-unit decrease, as printed
Observational data: associations, not effects.
Further findings
Mortality with SF-36 PCS <53.75, IPTW analysis in MPA and GPA (subgroup)
| HR (95% CI) | P value | ||
|---|---|---|---|
| SF-36 PCS <53.75 | 3.249 (1.169–9.033) | P = 0.024 | |
| 0.10.31310Hazard ratio (log scale) |
Baseline SF-36 scores · initial diagnosis
- Median SF-36 PCS
- 47.5
- Median SF-36 MCS
- 53.3
Deaths during follow-up
- Deaths, total
- 21 (11.1%)
- Deaths, MPA
- 15
- Deaths, GPA
- 6
Correlations of SF-36 PCS and MCS
- SF-36 PCS significantly but weakly associated with BVAS, Five-factor score, erythrocyte sedimentation rate (ESR) and CRP
- SF-36 MCS not associated with ESR
Original publication
Clinical association of health-related quality of life and mortality in an antineutrophil cytoplasmic antibody-associated vasculitis cohort. Semin Arthritis Rheum. Published 16 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →