Spondyloarthritis & psoriatic arthritis
Clinical and molecular links between chronic systemic inflammation and structural damage in axial spondyloarthritis
Authors' conclusion
Persistent systemic inflammation in axSpA is a key independent driver of structural damage and is linked to a distinct proteomic and functional signature involving neutrophil activation and bone remodeling.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) in a retrospective registryregistry
- Participants
- 238 patients
- Exposure
- Persistent vs intermediate vs non-persistent systemic inflammation
- Outcome
- Radiographic damage
Methodological detailsregistry-based, proteomic profiling (Olink 184-protein panel), in vitro assays in SaOS-2 osteoblast-like cells
- Registry-based
- Proteomic profiling (Olink 184-protein panel)
- In vitro assays in SaOS-2 osteoblast-like cells
Main finding
As reported in the abstract
Persistent
25.2%
Observational data: associations, not effects.
Further findings
Proteomic signature
- Distinct inflammatory signature in persistently inflamed patients: elevated MMP9, IL-6, CDCP1 and neutrophil-related proteins
- CDCP1 strongly correlated with radiographic damage and bone turnover markers
In vitro functional assays
- CDCP1 and C-reactive protein (CRP) modulate osteoblast gene expression, promoting osteogenic and inflammatory pathways dose-dependently
- Serum from persistently inflamed patients induced osteogenic remodeling in vitro
Original publication
Clinical and molecular links between chronic systemic inflammation and structural damage in axial spondyloarthritis. Arthritis Res Ther. Published 1 December 2025. doi:10.
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