Lupus & antiphospholipid syndrome
Circulating and renal fibrocytes are associated with interstitial fibrosis in lupus nephritis
Authors' conclusion
Fibrocytes were significantly increased in the blood and kidney tissue of patients with LN, especially those with interstitial fibrosis. Fibrocytes could be differentiated from blood cells, with an active contribution from RTECs.
Study context
- Population
- Patients with lupus nephritis (LN)
- Comparison
- Patients with LN vs healthy control
- Outcome
- Fibrocytes in blood and kidney
Methodological detailsflow cytometry and confocal imaging, in vitro LN sera-treated HK-2 cells
- Flow cytometry and confocal imaging
- In vitro LN sera-treated HK-2 cells
Main finding
As reported in the abstract
- Circulating fibrocytes (colI+α-SMA+CD34+CD45+) present in peripheral blood; abundance especially high in LN patients with interstitial fibrosis vs healthy control
- Renal fibrocytes (colI+α-SMA+CD45+) found in tubulointerstitium in LN; numbers significantly associated with chronicity indices incl. interstitial fibrosis and renal dysfunction
- PBMC stimulation with supernatants from LN serum-treated HK-2 cells led to significant fibrocyte generation, abrogated by IL-6 neutralizing antibody
Original publication
Circulating and renal fibrocytes are associated with interstitial fibrosis in lupus nephritis. Rheumatology (Oxford). Published 15 June 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →