Circulating Adipokines and Associations With Incident Cardiovascular Disease in Rheumatoid Arthritis
Authors' conclusion
Adipokines are associated with HF hospitalization and CVD-related death in patients with RA, with stronger associations in nonobese participants.
Study context
- Population
- Patients with rheumatoid arthritis (RA) with banked enrollment serum
- Participants
- 2,598 patients19,585 patient-years
- Exposure
- High vs low circulating adiponectin, leptin and FGF-21
- Outcome
- Incident CVD events:
- CAD
- Stroke
- HF hospitalization
- Venous thromboembolism
- CVD-related deaths
Methodological detailsmultivariable Cox models, adipokines dichotomized above/below the median
- Multivariable Cox models
- Adipokines dichotomized above/below the median
Main finding
As reported in the abstract
Incident CVD events by adipokine level
Hazard ratio (95% CI)P value
High adiponectinvs Low adiponectinHF hospitalization
1.39(1.07–1.79)
P = 0.01High adiponectinvs Low adiponectinCVD-related death
1.49(1.16–1.92)
P = 0.002High leptinvs Low leptinCVD-related death
1.44(1.05–1.97)
P = 0.02High FGF-21vs Low FGF-21CAD
0.75(0.58–0.97)
P = 0.03- At least 1 cardiovascular disease (CVD) event (all participants)
- 639 (25%)
Observational data: associations, not effects.
Further findings
CVD-related death, nonobese subgroup
- Associations of high adiponectin and leptin with CVD-related death driven by strong associations in nonobese patients
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Circulating Adipokines and Associations With Incident Cardiovascular Disease in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). Published 11 November 2022. doi:10.
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