Pain Sensitization as a Potential Mediator of the Relationship Between Sleep Disturbance and Subsequent Pain in Rheumatoid Arthritis
Authors' conclusion
Pain sensitization may be one mechanism through which sleep disturbance contributes to pain.
Study context
- Population
- Patients with active rheumatoid arthritis (RA) followed for 12 weeks after initiating a DMARD
- Participants
- 221 patients
- Outcome
- Mediation by pain sensitization (QST) of the effect of baseline sleep disturbance (Patient-Reported Outcomes Measurement Information System (PROMIS)) on subsequent pain intensity (PROMIS)
- Follow-up
- 12 weeks
Methodological detailsmediation analysis, adjusted for baseline confounding factors
- Mediation analysis
- Adjusted for baseline confounding factors
Main finding
As reported in the abstract
Sleep disturbance predicting subsequent pain; mediation by QST
Coefficient for a meaningful increase of 5 units in sleep disturbance (multiple regression), 95% CI 0.11, 0.50
0.32
Proportion of effect mediated by quantitative sensory testing (QST)
10-19%
Observational data: associations, not effects.
Further findings
Correlation of sleep disturbance with QST measures
- Sleep disturbance correlated with all QST measures except wrist temporal summation (TS) and conditioned pain modulation (CPM)
Original publication
Pain Sensitization as a Potential Mediator of the Relationship Between Sleep Disturbance and Subsequent Pain in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). Published 9 November 2022. doi:10.
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