Association Between Sleep Disturbance and Subsequent Pain Interference in Patients With Early Rheumatoid Arthritis
Study context
- Population
- Adults with early rheumatoid arthritis (RA) (joint symptoms ≤12 months) enrolled in the Canadian Early Arthritis Cohort, 2016–202368% female
- Participants
- 502 adults
- Exposure
- Sleep disturbance as predictor of pain interference 6 months later
- Outcome
- Pain interference (PROMIS) 6 months after each sleep disturbance assessment
- Follow-up
- 6, 12, 18 and 24 months
Methodological detailsmulticentre cohort (Canadian Early Arthritis Cohort), lagged linear mixed-effects models, crude and adjusted analyses
- Multicentre cohort (Canadian Early Arthritis Cohort)
- Lagged linear mixed-effects models
- Crude and adjusted analyses
Main finding
As reported in the abstract
Association of sleep disturbance with subsequent pain interference · 6 months later, over 24 months
- Significant association in unadjusted and adjusted models: worse sleep 6 months prior associated with greater pain interference at the following 6-month evaluation
- Adjusted for age, sex, BMI, education, income, smoking status, comorbidities, disease activity, treatment and depression
Observational data: associations, not effects.
Original publication
Association Between Sleep Disturbance and Subsequent Pain Interference in Patients With Early Rheumatoid Arthritis. Arthritis Care Res (Hoboken). Published 23 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →