Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis
Authors' conclusion
Elevations in adipokines are associated with an increased risk of fracture in patients with RA, independent of other established risk factors including BMI, smoking, and prednisone use.
Study context
- Population
- Participants in a longitudinal rheumatoid arthritis (RA) cohort (89% male, mean age 72 years)
- Participants
- 2,527 participants27,540 person-years
- Exposure
- High vs low circulating adipokine levels
- Outcome
- Incident osteoporotic fracture (diagnostic-code algorithms, confirmed by chart review)
Methodological detailslongitudinal RA cohort, banked enrollment serum, Cox proportional hazard models, adjusted
- Longitudinal RA cohort
- Banked enrollment serum
- Cox proportional hazard models, adjusted
Main finding
As reported in the abstract
Incident fracture, high vs low adipokine levels
Hazard ratio (95% CI)P value
High leptinvs Low leptinadjusted
1.47(1.15–1.90)
P = 0.003High FGF-21vs Low FGF-21adjusted
1.39(1.16–1.67)
P < 0.001High adiponectinvs Low adiponectinadjusted; not significant
1.21(0.94–1.55)
P = 0.13- Incident fractures
- 228
- Fracture rate per 1,000 person-years
- 8.3
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident fracture, all three adipokines elevatedvs none elevated | 2.17 (1.27–3.70) | P = 0.005 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis. Arthritis Care Res (Hoboken). Published 29 November 2025. doi:10.
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