Loss of muscle and bone mass with increased adiposity and fractures in patients with chronic obstructive pulmonary disease: A 5-year follow-up cohort study
Authors' conclusion
Over a 5-year follow-up, COPD patients experience a significant loss of BMD and lean mass, along with increased adiposity and fractures.
Study context
- Population
- Patients with Chronic obstructive pulmonary disease (COPD) from a tertiary hospital (mean age 69.0 ± 7.5 years; 21 women)21 women
- Participants
- 40 patients
- Exposure
- Baseline vs final assessment after median 58 months
- Outcome
- Changes in body composition (ALM, body fat, fat mass index by DXA) and BMD, and occurrence of fractures
- Follow-up
- Median 58 months
Methodological detailsobservational, single-centre (tertiary hospital), 5-year follow-up
- Observational
- Single-centre (tertiary hospital)
- 5-year follow-up
Main finding
As reported in the abstract
- Vertebral fractures, baseline vs final
- 22.5% versus 38.5%; P = 0.031
- Non-vertebral fractures, baseline vs final
- 12.5% versus 17.5%; P < 0.001
- Appendicular lean mass (ALM), baseline vs final (kg/m²)
- 17.5 ± 4.0 versus 16.5 ± 4.1; P < 0.001
- Total femur bone mineral density (BMD), baseline vs final (g/cm²)
- 0.901 ± 0.144 versus 0.862 ± 0.136; P < 0.001
- Fat mass index (FMI), baseline vs final (g/cm² as printed)
- 8.5 ± 5.4 versus 11.8 ± 5.8; P < 0.001
Observational data: associations, not effects.
Further findings
Predictor of fat mass loss: serum 25-hydroxyvitamin D < 30 ng/mL
- OR
- 8.33, 95% CI 1.16-59.93; P = 0.035
Predictor of bone loss at the spine: baseline lumbar spine BMD
- OR
- 1.05, 95% CI 1.01-1.10; P = 0.037
Predictor of combined bone loss and incident fracture: higher airflow obstruction
- OR
- 22.04, 95% CI 1.17-416.52; P = 0.039
Original publication
Loss of muscle and bone mass with increased adiposity and fractures in patients with chronic obstructive pulmonary disease: A 5-year follow-up cohort study. Osteoporos Int. Published 22 November 2025. doi:10.
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