Spondyloarthritis & psoriatic arthritis
Cigarette Smoking Increases the Prevalence of Hip Joint Involvement in Ankylosing Spondylitis: A Real-World Case-Control Study
Authors' conclusion
Smoking is a novel independent risk factor for hip involvement in AS; even exposure of less than 10 pack-years could contribute to increased prevalence of hip involvement in AS
Study context
- Population
- Patients with ankylosing spondylitis (AS), real-world setting
- Participants
- 103 vs 89
- Comparison
- AS with vs without hip involvement; association with cigarette smoking
- Casesn = 103
- Controlsn = 89reference
- Outcome
- Association between cigarette smoking and hip joint involvement in AS
Methodological detailslogistic regression, subgroup analysis, sensitivity analysis
- Logistic regression
- Subgroup analysis
- Sensitivity analysis
Main finding
As reported in the abstract
Hip involvement, independent associations (adjusted)
Cigarette smoking, aOR
7.23
95% CI 2.27–23.05
JAS, aOR
2.52
95% CI 1.26–5.06
Male sex, aOR
2.89
95% CI 1.14–7.33
Observational data: associations, not effects.
Further findings
Hip involvement, smoking exposure <10 pack-years vs none
- <10 pack-years vs no smoking, aOR
- 2.21 (95% CI 1.09-4.47)
Smoking–hip involvement association in subgroups (males; propensity score-matched) and sensitivity analysis
- Association reproduced in males and propensity score-matched subjects; withstood sensitivity analysis
Original publication
Cigarette Smoking Increases the Prevalence of Hip Joint Involvement in Ankylosing Spondylitis: A Real-World Case-Control Study. J Rheumatol. Published 15 January 2023. doi:10.
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