Spondyloarthritis & psoriatic arthritis
Achilles enthesitis on physical examination leads to worse outcomes after 2 years of follow up in patients with ankylosing spondylitis from REGISPONSER-AS registry
Authors' conclusion
In patients with AS, the presence of Achilles' tendon enthesitis was associated with worse scores on the outcome measures after 2 years of follow-up, leading to a lower probability of achieving low disease activity.
Study context
- Population
- Patients with ankylosing spondylitis (AS) in the REGISPONSER-AS registry, 2 years of follow-up
- Participants
- 749 patients
- Exposure
- Achilles enthesitis at baseline vs no Achilles enthesitis
- Achilles enthesitisn = 46
- Outcome
- Impact of baseline Achilles enthesitis on outcome measures (PROs)
- Follow-up
- 2 years
Methodological detailsobservational, registry-based (REGISPONSER-AS), linear regression and mixed models adjusted for age, body mass index (BMI) and anti-TNF intake
- Observational
- Registry-based (REGISPONSER-AS)
- Linear regression and mixed models adjusted for age, BMI and anti-TNF intake
Main finding
As reported in the abstract
ASDAS low disease activity (ASDAS < 2.1)
P = 0.030
Observational data: associations, not effects.
Further findings
Patient-reported outcome (PRO) scores at baseline
- Higher global VAS, BASDAI, mBASDAI, ASDAS-CRP and BASFI with Achilles enthesitis vs without
Original publication
Achilles enthesitis on physical examination leads to worse outcomes after 2 years of follow up in patients with ankylosing spondylitis from REGISPONSER-AS registry. Arthritis Res Ther. Published 13 January 2023. doi:10.
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