Systemic sclerosis & Raynaud's
Chemokine receptor CXCR4 based positron emission tomography imaging in systemic sclerosis-related interstitial lung disease
Authors' conclusion
In SSc-ILD, CXCR4 expression is upregulated in both lung parenchyma and peripheral T cells, significantly in progressive and UIP subsets.
Study context
- Population
- Patients with SSc-ILD
- Exposure
- SSc-ILD patients vs controls
- Outcome
- Whole-lung CXCR4 uptake on PET, median SUVmean
Methodological detailsPositron emission tomography (PET) imaging (68Ga-CPCR4), flow cytometry, subset analysis
- PET imaging (68Ga-CPCR4)
- Flow cytometry
- Subset analysis
Main finding
As reported in the abstract
SSc-ILD
0.56
median
P < 0.0001
- Highest AUC in dorsobasal regions
- 0.91
- Highest AUC in reticular with architecturally distorted areas
- 0.95
Observational data: associations, not effects.
Further findings
Median
| Outcome | Progressive | Early | Stable | P value |
|---|---|---|---|---|
| Whole-lung median SUVmean by clinical subsetProgressive vs Early | 0.73 | 0.49 | 0.45 | P < 0.0001 |
| Whole-lung median SUVmean by clinical subsetProgressive vs Stable | P < 0.0001 |
- CXCR4 uptake by ILD pattern · UIP vs NSIP · higher uptake in UIP
- P = 0.0032
- Peripheral CXCR4+ T cells, SSc-ILD vs controls · higher CD4+CXCR4+ T cells
- P = 0.0003
- Peripheral CXCR4+ T cells, SSc-ILD vs controls · higher CD8+CXCR4+ T cells
- P = 0.0013
Whole-lung median SUVmean by clinical subset
- Progressive subset had higher AUC than early and stable subsets
CXCR4 uptake by anti-Scl70 status
- Trend for higher uptake in anti-Scl70 positive vs negative patients
Peripheral CXCR4+ T cells, SSc-ILD vs controls
- Moderate to strong correlation with lung parenchymal regions
Original publication
Chemokine receptor CXCR4 based positron emission tomography imaging in systemic sclerosis-related interstitial lung disease. Rheumatology (Oxford). Published 23 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →