Chemokine CXCL9, a marker of inflammaging, is associated with changes of muscle strength and mortality in older men
Authors' conclusion
Greater serum levels of CXCL9 were significantly associated with a decline in chair stands and increased mortality.
Study context
- Population
- Older men from the Osteoporotic Fractures in Men (MrOS) Study who attended the third and fourth clinic visitsrandom sample of MrOS
- Participants
- 300 men
- Exposure
- Serum CXCL9 quartiles
- Outcome
- Cross-sectional and longitudinal musculoskeletal outcomes (6 m walking speed, chair stands, hip BMD, major osteoporotic fracture) and mortality
Methodological detailsrandom sample from the MrOS cohort, linear regression, Cox proportional hazards models
- Random sample from the MrOS cohort
- Linear regression
- Cox proportional hazards models
Main finding
As reported in the abstract
Mean CXCL9 level (pg/ml), participants aged 79.1 ± 5.3 years
196.9 ± 135.2
Change in chair stands with higher CXCL9 (β), after multivariable adjustment
- 1.098
p < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| MortalityQ4vs Q1 | 1.98 (1.25–3.14) | P for trend < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Chemokine CXCL9, a marker of inflammaging, is associated with changes of muscle strength and mortality in older men. Osteoporos Int. Published 4 July 2024. doi:10.
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