B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials
Pooled result · Fracture incidenceResult — go to the resultRelative risk 1.06 95% CI 0.95–1.18Authors' conclusion
Available evidence from RCTs does not support VBs can effectively influence osteoporotic fracture risk, BMD, and BTMs.
Study context
- Participants
- 34,700 participants14 RCTs
- Comparison
- B vitamins supplements vs control
- Outcome
- Fracture incidence, BMD and bone turnover markers (BTMs)
Methodological detailstrial sequential analysis, GRADE, sensitivity and publication bias analyses
- Trial sequential analysis
- GRADE
- Sensitivity and publication bias analyses
Pooled result
Fracture incidence
Relative risk
1.06
95% CI 0.95–1.18
P = 0.33
B vitamins (folate, B6, B12) supplementsvs control
RR 1.06 (95% CI 0.95–1.18); P = 0.33
As reported in the abstract
Further pooled results
| Outcome | P value |
|---|---|
| Serum carboxy-terminal peptide (bone resorption)I2 = 0%; increased with VBs | P = 0.009 |
Bone mineral density (BMD) (lumbar spine and femur neck)
- VBs did not affect BMD in lumbar spine and femur neck
- Trial sequential analysis (TSA): data may not be enough to draw sufficient conclusions
Bone specific alkaline phosphatase (bone formation)
- No significant effect of VBs
Original publication
B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials. Osteoporos Int. Published 2 July 2024. doi:10.
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