Lupus & antiphospholipid syndrome
Characterizing arthritis subtypes in lupus: prevalence, clinical features and role of type I interferon signatures
Authors' conclusion
Distinct clinical and serological patterns differentiate JA and CIDA, suggesting unique underlying mechanisms of deforming arthritis in SLE. Both NDA and JA exhibited a high IFN signature, while CIDA showed a higher joint burden, lower disease activity and lower IFN signature relative to NDA.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE), University of Toronto Lupus Clinic (July 1970-August 2024)1,248 with arthritis
- Participants
- 2,264 patients
- Exposure
- Arthritis subtypes in SLE: Jaccoud's arthropathy (JA) and CIDA vs non-deforming arthritis (NDA)
- NDAn = 908reference
- JAn = 239
- CIDAn = 101
- Outcome
- Prevalence of arthritis subtypes in SLE and their associations, including type I IFN scores
Methodological detailssingle-centre, univariable and multivariable logistic regression, NDA as reference
- Single-centre
- Univariable and multivariable logistic regression
- NDA as reference
Main finding
As reported in the abstract
- Arthritis (any subtype)
- 1248 (55.1%)
Observational data: associations, not effects.
Further findings
| Outcome | OR | |
|---|---|---|
| Factors associated with JA vs NDA (multivariable logistic regression)JAvs NDALonger disease duration | 1.05 (95% CI 1.03–1.08) | |
| Factors associated with JA vs NDA (multivariable logistic regression)JAvs NDAFemale sex | 2.06 (95% CI 1.11–3.83) | |
| Factors associated with CIDA vs NDA (multivariable logistic regression)CIDAvs NDANeurological involvement | 1.79 (CI 1.13–2.84) | |
| Factors associated with CIDA vs NDA (multivariable logistic regression)CIDAvs NDAanti-Ro antibodies | 1.71 (CI 1.01–2.90) | |
| Factors associated with CIDA vs NDA (multivariable logistic regression)CIDAvs NDAAdjusted mean joint count | 1.09 (CI 1.03–1.77) | |
| Factors associated with CIDA vs NDA (multivariable logistic regression)CIDAvs NDAAdjusted mean SLEDAI-2K over follow-up | 0.89 (CI 0.81–0.98) | |
| 0.20.5125Odds ratio (log scale) |
Interferon (IFN) signature (subgroup with available IFN scores, n = 475)
- CIDA associated with a low IFN signature in unadjusted analysis, whereas both JA and NDA had a high IFN signature
Original publication
Characterizing arthritis subtypes in lupus: prevalence, clinical features and role of type I interferon signatures. Rheumatology (Oxford). Published 22 July 2026. doi:10.
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