Autoinflammatory & rare systemic diseases
Characterization of latent allergen profile and association with clinical features in patients with IgG4-related disease
Authors' conclusion
Our study characterized the allergen profile in IgG4-RD patients, and reported its association with enhanced inflammation and distinct organ involvement.
Study context
- Population
- Patients with IgG4-related disease (IgG4-RD) and healthy controls
- Participants
- 100 vs 40
- Exposure
- IgG4-RD vs healthy controls
- IgG4-RDn = 100
- Healthy controls (HCs)n = 40reference
- Outcome
- AsIgE positivity rate and allergen profile
Main finding
As reported in the abstract
AsIgE-positive rate
P < 0.001
Observational data: associations, not effects.
Further findings
Most frequently detected allergens in IgG4-RD
- House dust mites
- 47%
- Cockroach
- 26%
- Moulds
- 14%
- Grasses
- 14%
Allergen-specific IgE (AsIgE) positivity and inflammatory markers
- Positive AsIgE associated with high total IgE
- P < 0.0001
- Positive AsIgE associated with high TNF-α
- P < 0.05
Number of detected allergens per patient, correlations
- Positive correlation with serum IgG4
- P < 0.0001
- Positive correlation with total IgE (T-IgE)
- P < 0.0001
- Inverse correlation with C3
- P < 0.0001
- Inverse correlation with C4
- P < 0.001
Allergen-specific IgE and organ involvement
- Cockroach-sIgE with ureter involvement
- P < 0.05
- Cockroach-sIgE with sinus involvement
- P < 0.05
- Mulberry-sIgE with renal involvement
- P < 0.01
- Moulds-sIgE with orbital involvement
- P < 0.05
- Moulds-sIgE with lacrimal involvement
- P < 0.01
AsIgE-AsIgG4 correlation
- No significant AsIgE-AsIgG4 correlation
- AsIgG4 measured in 20 patients with higher serum IgG4 and AsIgE levels
Original publication
Characterization of latent allergen profile and association with clinical features in patients with IgG4-related disease. Rheumatology (Oxford). Published 18 January 2026. doi:10.
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