Autoinflammatory & rare systemic diseases
Greyscale, colour Doppler and oscillometric macroangiopathy indices in patients with autoinflammatory syndromes: the INFLAMMACARD cohort
Authors' conclusion
In the first CV surrogate marker study in AIS combining oscillometry and arterial US, patients exhibited increased carotid pulsatility and altered flow dynamics vs controls. Aortic stiffness was lower in patients receiving biologics and mainly predicted by traditional CV factors and lymphadenopathy.
Study context
- Population
- Patients with autoinflammatory syndromes (AIS) and matched healthy controls1:2 matched
- Participants
- 31 vs 62
- Exposure
- AIS patients vs matched healthy controls
- AISn = 31
- Controlsn = 62reference
- Outcome
- Common carotid artery (CCA) pulsatility index (colour Doppler ultrasound (CDUS))
Methodological detailsmatched (1:2) healthy controls, INFLAMMACARD cohort
- Matched (1:2) healthy controls
- INFLAMMACARD cohort
Main finding
As reported in the abstract
AIS
1.89
SD 0.46
Controls
1.59
SD 0.32
P = 0.024
Observational data: associations, not effects.
Further findings
CCA peak systolic velocity
P = 0.003
| Outcome | P value |
|---|---|
| cfPWV in AIS patients not receiving biologic therapy (subgroup)AIS not on biologics vs Comparator · comparator group not named in abstract | P = 0.001 |
- Carotid-femoral pulse wave velocity (cfPWV) in AIS patients not receiving biologic therapy (subgroup): AIS not on biologics 6.99 (SD 1.71) m/s
- cfPWV in AIS patients not receiving biologic therapy (subgroup): Comparator 5.86 (SD 0.81) m/s
Predictors of cfPWV and carotid intima-media thickness (cIMT)
- Age with cfPWV, rho
- 0.573 (P < 0.001)
- Age with cIMT, rho
- 0.675 (P = 0.002)
- Systolic arterial pressure (SAP) with cfPWV, r
- 0.464 (P = 0.009)
- SAP with cIMT, rho
- 0.514 (P = 0.029)
- Lymphadenopathy with cfPWV, eta
- 0.373 (P = 0.039)
Associations of pulsatility index (PI) and flow-velocity integral (FVI)
- PI with nicotine, rho
- 0.691 (P = 0.008)
- FVI (inversely) with SAP, rho
- −0.522 (v0.026)
Original publication
Greyscale, colour Doppler and oscillometric macroangiopathy indices in patients with autoinflammatory syndromes: the INFLAMMACARD cohort. Rheumatology (Oxford). Published 10 January 2026. doi:10.
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