Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases
Authors' conclusion
Our cross-sectional data of COVID-19 infections in patients with IRD showed a significant reduction of hospitalisation due to infection in double-vaccinated or triple-vaccinated patients compared with those without vaccination and even a significant reduction of COVID-19-related deaths in triple-vaccinated patients.
Study context
- Population
- Patients with inflammatory rheumatic diseases and SARS-CoV-2 infection, German COVID-19-IRD registry, February 2021 to July 2022
- Participants
- 2,314 patients
- Exposure
- Double-vaccinated and triple-vaccinated vs unvaccinated patients with IRD and SARS-CoV-2 infection
- Unvaccinatedn = 923reference
- Double-vaccinatedn = 551
- Triple-vaccinatedn = 803
- Quadruple-vaccinatedn = 37
- Outcome
- COVID-19-related hospitalisation
Methodological detailsphysician-reported registry, multivariable logistic regression
- Physician-reported registry
- Multivariable logistic regression
Main finding
As reported in the abstract
Each group vs unvaccinatedOdds ratio (95% CI)
Double-vaccinated
0.43(0.29–0.62)
Triple-vaccinated
0.13(0.08–0.21)
- Hospitalisation across vaccination groups
- P < 0.001
Observational data: associations, not effects.
Further findings
COVID-19-related death, multivariable analysis
| OR (95% CI) | ||
|---|---|---|
| Third vaccinationMultivariable analysis | 0.26 (0.01–0.73) | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | Unvaccinated | Double-vaccinated | Triple-vaccinated |
|---|---|---|---|
| Time from vaccination to SARS-CoV-2 infectionMedian, days | — not stated in the abstract | 151 (range 14–347) | 88 (range 14–270) |
| Mortality | 2% | 1.8% | 0.6% |
— not stated in the abstract
Original publication
Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases. RMD Open. Published 17 April 2023. doi:10.
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