Revaccination of patients with systemic lupus erythematosus or rheumatoid arthritis without an initial COVID-19 vaccine response elicits seroconversion in half of the patients
Authors' conclusion
Forty-seven percent of initial non-responders seroconverted after two-dose revaccination but still had lower levels of SARS-CoV-2 antibodies compared with controls and blood donors. RD patients without a detectable serological response after the initial COVID-19 mRNA vaccine had a T-cell response similar to immunocompetent controls and blood donors.
Study context
- Population
- Patients with rheumatic diseases (RD) (SLE or RA) from a cohort vaccinated with the standard two-dose COVID-19 vaccinations; blood donors
- Participants
- 17 / 29 / 32
- Exposure
- Initial vaccine non-responders vs responders and blood donors
- Casesn = 17
- Controlsn = 29reference
- Blood donorsn = 32
- Outcome
- Antibody response (seroconversion; detectable neutralising antibodies) after COVID-19 mRNA revaccination (two doses)
- Follow-up
- Six weeks after completed revaccination
Methodological detailscase-control design, revaccination with two doses of COVID-19 mRNA vaccine
- Case-control design
- Revaccination with two doses of COVID-19 mRNA vaccine
Main finding
As reported in the abstract
Detectable neutralising antibodies after revaccination
Cases
47%
Observational data: associations, not effects.
Further findings
Measurable B-cells before revaccination
- Measurable B-cells before revaccination among cases who seroconverted
- 50%
Antibody class switch in cases
- Revaccination induced a decrease in IgM and increase in IgG in cases
T-cell responses before and after revaccination
- No significant difference between the three groups
Original publication
Revaccination of patients with systemic lupus erythematosus or rheumatoid arthritis without an initial COVID-19 vaccine response elicits seroconversion in half of the patients. Clin Exp Rheumatol. Published 16 April 2023. doi:10.
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