Lupus & antiphospholipid syndrome
Characterisation and outcomes of different subsets of low disease activity states in patients with systemic lupus erythematosus
Authors' conclusion
This study confirms that all subsets of LLDAS are associated with reduced flare and damage accrual. However, LLDAS without any clinical or serological activity has the strongest protective association with severe flares.
Study context
- Population
- Patients with SLE in a prospective multinational cohort, March 2013–December 2020, in lupus low disease activity state (LLDAS) at least once; visits fulfilling both LLDAS and Definition of Remission in SLE (DORIS) excluded
- Participants
- 2,099 patients6,150 LLDAS non-DORIS visits
- Exposure
- LLDAS subsets vs non-LLDAS
- Outcome
- Flares and damage accrual by LLDAS subset
Methodological detailsmultinational, multivariable regression analysis, median follow-up 3.5 (IQR 1.3-5.8) years
- Multinational
- Multivariable regression analysis
- Median follow-up 3.5 (IQR 1.3-5.8) years
Main finding
As reported in the abstract
Distribution of LLDAS (not DORIS) visits by subset
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Severe flares · ensuing 6 monthsLLDAS with no clinical or serological activityvs LLDAS with clinical activity | 0.47 (0.27–0.82) | P = 0.007 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Characterisation and outcomes of different subsets of low disease activity states in patients with systemic lupus erythematosus. Lupus Sci Med. Published 18 September 2024. doi:10.
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