Cardiovascular Risk Profile and Osteoarthritis—Considering Sex and Multisite Joint Involvement: A Canadian Longitudinal Study on Aging
Authors' conclusion
Findings suggest unique CVD risks by sex/multisite subgroups and point to a potentially important role for inflammation in OA over and above traditional CVD risk factors.
Study context
- Population
- Canadian Longitudinal Study on Aging, Cycle 1 Comprehensive Cohort, ages 45 to 85 years; median age 63 years, 55.8% womenage- and sex-matched
- Participants
- 6,098 participants
- Exposure
- Osteoarthritis (OA) vs age- and sex-matched non-OA controls
- OAn = 3,049
- Outcome
- Latent CVD risk quartiles (lowest, mid-low, mid-high, highest) derived from hsCRP, HDL, triglycerides, total cholesterol, BMI, systolic blood pressure, HbA1c and smoking, by sex
Methodological detailsage- and sex-matched, ordinal logistic regression, latent cardiovascular disease (CVD) risk variable
- Age- and sex-matched
- Ordinal logistic regression
- Latent CVD risk variable
Main finding
As reported in the abstract
CVD risk quartiles
- Highest risk category: one-third of OA vs one-fifth of non-OA respondents
- OA associated with worse CVD risk quartiles vs non-OA overall
- Women with multisite OA: increasingly associated with worse CVD risk quartiles with increasing risk thresholds; not in men
Observational data: associations, not effects.
Further findings
Contributors to latent CVD risk by sex
- Body mass index (BMI) the largest contributor in both sexes; High-sensitivity C-reactive protein (hsCRP) predominant in women; metabolic factors and smoking predominant in men
Original publication
Cardiovascular Risk Profile and Osteoarthritis—Considering Sex and Multisite Joint Involvement: A Canadian Longitudinal Study on Aging. Arthritis Care Res (Hoboken). Published 20 November 2022. doi:10.
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