Spondyloarthritis & psoriatic arthritis
Burden and determinants of multi-b/tsDMARD failure in psoriatic arthritis
Authors' conclusion
In this cohort, 17% patients with PsA experienced multi-b/tsDMARD failure. These patients were more likely to be female, obese, and have higher rates of axial involvement and depression, along with higher active disease activity.
Study context
- Population
- Psoriatic arthritis (PsA) patients enrolled in an observational, longitudinal registry at the NYU Psoriatic Arthritis Center725 used ≥1 b/tsDMARD
- Participants
- 960 patients
- Exposure
- Multi-b/tsDMARD failure vs 1 b/tsDMARD
- Multi-b/tsDMARD failuren = 166
- Outcome
- Multi-b/tsDMARD failure (requiring ≥ 4 b/tsDMARDs) and its risk factors
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Multi-b/tsDMARD failure: prevalence and risk factors vs 1 b/tsDMARD (adjusted for age, disease duration, sex, depression, smoking, obesity, skin severity)
Multi-b/tsDMARD failure
17%
166
Each group vs 1 b/tsDMARDOdds ratio (95% CI)
Female sex
2.3(1.4–3.8)
Axial disease
2.1(1.2–3.6)
Depression
2.0(1.1–3.7)
Obesity
1.7(1.0–2.8)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Disease activity at clinical visit (swollen joint count)Increased disease activity in multi-b/tsDMARD failure | P = 0.005 |
Use of ≥1 b/tsDMARD during disease course
- Patients who used ≥ 1 b/tsDMARD
- 725 (75%)
- Initial b/tsDMARDs predominately anti-TNF agents
Original publication
Burden and determinants of multi-b/tsDMARD failure in psoriatic arthritis. Arthritis Res Ther. Published 4 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →