Bone erosions associated with systemic bone loss on HR-pQCT in women with longstanding polyarticular juvenile idiopathic arthritis
Authors' conclusion
Bone erosions in longstanding pJIA women were associated with decreased cortical bone parameters, and these patients showed systemic bone impairment at peripheral sites compared with healthy controls.
Study context
- Population
- Women with longstanding polyarticular juvenile idiopathic arthritis (pJIA) (mean age 31.5 ± 7.4 yrs; mean disease duration 21.7 ± 9.2 yrs) and healthy controls
- Exposure
- Women with longstanding pJIA vs healthy controls; association of bone erosions with systemic bone loss in pJIA
- pJIAn = Thirty-four
- Healthy controls (HC)n = 99reference
- Outcome
- Association between bone erosions (HR-pQCT of 2nd and 3rd metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints, dominant hand) and systemic bone loss (radius and tibia HR-pQCT)
Methodological detailsHR-pQCT, healthy controls
- HR-pQCT
- Healthy controls
Main finding
As reported in the abstract
Number of bone erosions vs systemic bone parameters in pJIA
- Correlation with Ct.Po at tibia
- r = 0.575, p = 0.001
- Correlation with Ct.Po at radius
- r = 0.423, p = 0.018
- Correlation with cortical volumetric bone mineral density (vBMD) at tibia
- r=−0.420, p = 0.015
- Presence of erosions independently associated with Ct.Po at radius (logistic regression adjusted for anti-CCP)
- p = 0.018
- Presence of erosions independently associated with cortical vBMD at tibia (logistic regression adjusted for anti-CCP)
- p = 0.020
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Systemic bone parameters, pJIA vs HC | P < 0.05 |
- Systemic bone parameters, pJIA vs HC: cortical and trabecular vBMD, trabecular number, and μ-finite element parameters decreased in patients
Bone erosions detectable (prevalence, patients)
- Bone erosions detectable in patients
- 79%
Original publication
Bone erosions associated with systemic bone loss on HR-pQCT in women with longstanding polyarticular juvenile idiopathic arthritis. Semin Arthritis Rheum. Published 5 August 2023. doi:10.
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