Biomechanical determinants of rheumatoid arthritis severity and excess cardiovascular disease: common origins of two complex diseases
Authors' conclusion
Articular, arterial and skin stiffness correlated with each other and with RA severity.
Study context
- Population
- Patients with anti-CCP antibody (ACPA)-positive rheumatoid arthritis (RA) and controls
- Participants
- 58 vs 57
- Exposure
- ACPA-positive RA vs controls
- RAn = 58
- Controlsn = 57reference
- Outcome
- Associations of articular, arterial and skin stiffness with RA severity
Main finding
As reported in the abstract
High radiographic rate associated with greater metacarpophalangeal (MCP) articular stiffness (t test)
p 0.014
High radiographic rate associated with greater arterial stiffness
p 0.044
High radiographic rate associated with greater skin stiffness, in RA <5 years duration
p 0.002
Observational data: associations, not effects.
Further findings
Determinants of arterial stiffness in RA
- Arterial stiffness correlated with age (ß)
- P < 0.005
- Arterial stiffness correlated with articular stiffness (ß)
- P < 0.001
- Arterial stiffness correlated with skin stiffness (ß)
- p 0.037
- Arterial stiffness correlated inversely with alcohol consumption
- p 0.035
Original publication
Biomechanical determinants of rheumatoid arthritis severity and excess cardiovascular disease: common origins of two complex diseases. RMD Open. Published 21 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →