Characterizing Nonarticular Pain at Early Rheumatoid Arthritis Diagnosis: Evolution Over the First Year of Treatment and Impact on Remission in a Prospective Real‐World Early Rheumatoid Arthritis Cohort
Authors' conclusion
Regional NAP is common and persistent in early RA and impacts remission. RA activity may contribute to NAP.
Study context
- Population
- Participants with active early rheumatoid arthritis (RA) (symptoms <1 year and CDAI >2.8) enrolled January 2017–January 2022 who completed a body pain diagram over 1 year70% female
- Participants
- 392 participants
- Exposure
- Regional or widespread nonarticular pain (NAP) vs no NAP
- Outcome
- CDAI remission
- Follow-up
- 1 year
Methodological detailsreal-world, longitudinal, multicenter, generalized estimating equations
- Real-world
- Longitudinal
- Multicenter
- Generalized estimating equations
Main finding
As reported in the abstract
CDAI remission by NAP pattern · over 1 year
AOR for reaching CDAI remission (95% CI)
REGIONALvs NONE
0.42(0.26–0.70)
WIDESPREADvs NONE
0.30(0.12–0.74)
Observational data: associations, not effects.
Further findings
NAP at baseline
- More than half reported NAP; most presented with regional NAP
- 73%
- Regional NAP pattern: axial
- 40%
- Regional NAP pattern: upper quadrants
- 17%
Evolution of NAP over 1 year
- Regional NAP persisted or worsened
- 43%
- Widespread NAP resolved or improved
- 73%
Joint inflammation by NAP area
- Joint inflammation more frequently reported in areas with NAP vs areas without NAP
Original publication
Characterizing Nonarticular Pain at Early Rheumatoid Arthritis Diagnosis: Evolution Over the First Year of Treatment and Impact on Remission in a Prospective Real‐World Early Rheumatoid Arthritis Cohort. Arthritis Rheumatol. Published 21 November 2024. doi:10.
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