Baseline characteristics of the TRANSLATE2 cohort: A prospective study on rheumatoid arthritis-associated interstitial lung disease
Authors' conclusion
The TRANSLATE2 cohort provides a comprehensive and deeply phenotyped dataset that offers a unique opportunity to investigate the genetic architecture, risk factors, and natural history of RA-ILD.
Study context
- Population
- Patients fulfilling the ACR/EULAR 2010 classification criteria for rheumatoid arthritis (RA), consecutively included
- Participants
- 506 patients
- Comparison
- RA-ILD cases vs RA controls without interstitial lung disease (ILD)
- RA-ILDn = 275
- RA-noILDn = 231reference
- Outcome
- Baseline characteristics and determinants associated with ILD in RA
- Follow-up
- Baseline
Methodological detailsnational, multicentre, 5-year prospective follow-up, univariable and multivariable logistic regression
- National
- Multicentre
- 5-year prospective follow-up
- Univariable and multivariable logistic regression
Main finding
As reported in the abstract
Estimate (95% CI)
Male sexvs Female sex
OR 1.82(1.06–3.14)
Older age at RA onset
OR per 10 years 1.28(1.10,1.50)
Observational data: associations, not effects.
Further findings
Male sex · baseline
Age at enrollment · baseline
Age at RA onset · baseline
High-resolution computed tomography (HRCT) patterns in ILD cases · baseline
- Definite usual interstitial pneumonia
- 39.3%
- Non-specific interstitial pneumonia
- 17.8%
Respiratory symptoms and lung function at enrollment (ILD cases)
- Respiratory symptoms
- 67.3%
- Mean FVC % predicted (SD)
- 87.6% (21.7)
- Mean DLCO % predicted (SD)
- 58.4% (18.8)
Original publication
Baseline characteristics of the TRANSLATE2 cohort: A prospective study on rheumatoid arthritis-associated interstitial lung disease. Joint Bone Spine. Published 17 October 2025. doi:10.
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