Autoantibodies to Disease‐Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis
Authors' conclusion
A multiplex immunoassay with peptides from disease-related proteins in joints was found to be useful for detection of specific autoantibodies in RA serum. Of note, this immunoassay had high discriminatory capacity for early seronegative RA.
Study context
- Population
- Patients with rheumatoid arthritis (RA) (3 independent cohorts), Swedish healthy controls, and patients with osteoarthritis (OA), PsA and systemic lupus erythematosus (SLE)3 RA cohorts, n = 2,110
- Comparison
- Multiplex immunoassay of autoantibodies to joint-derived peptides in RA vs healthy controls, OA, PsA and SLE
- RAn = 2,110
- Outcome
- Discrimination of RA from healthy controls by 5 peptide antigens (screening)
Methodological detailsmultiplex bead-based flow immunoassay, 3 independent RA cohorts, age- and sex-matched healthy controls
- Multiplex bead-based flow immunoassay
- 3 independent RA cohorts
- Age- and sex-matched healthy controls
Performance
As reported in the abstract
| Test or model | Specificity | Specificity 95% CI |
|---|---|---|
| RA | 99% | 98-100% |
RA
Specificity99%
Specificity 95% CI98-100%
Further findings
| Outcome | Values |
|---|---|
| Early RA seronegative for anti-CCP and RF identified by the novel biomarkers | RA 22.5% (95% CI 19–26%) |
- Early RA seronegative for anti-CCP and RF identified by the novel biomarkers: confirmed in validation studies using 2 independent RA cohorts and OA, PsA and SLE cohorts
Discrimination of RA vs OA, PsA and SLE (validation in 2 other RA cohorts)
- Autoantibodies had high discriminatory capacity for RA vs OA, PsA and SLE
Original publication
Autoantibodies to Disease‐Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis. Arthritis Rheumatol. Published 27 April 2023. doi:10.
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