Associations between magnetic resonance imaging (MRI) features and pain in first metatarsophalangeal joint osteoarthritis
Authors' conclusion
MRI-detected bone marrow lesions in the first metatarsal head and cartilage loss are associated with pain severity in first MTP joint OA.
Study context
- Population
- Participants aged 36 to 74 years (mean [SD] = 57.5 [8.8]) with first metatarsophalangeal (MTP) joint osteoarthritis (OA) enrolled in two randomised trials
- Participants
- 80 participants
- Outcome
- Association of MRI features with pain severity (VAS)
Methodological detailsbaseline data from two randomised trials, multivariable linear regression, exploratory stepwise forward-selection
- Baseline data from two randomised trials
- Multivariable linear regression
- Exploratory stepwise forward-selection
Main finding
As reported in the abstract
- First metatarsal head bone marrow lesions (involving >66% of the first metatarsal head) associated with pain severity, adjusted analysis
- p = 0.025
- First metatarsal head bone marrow lesions associated with pain severity, stepwise analysis
- p = 0.039
- Cartilage loss associated with pain severity, stepwise analysis
- p = 0.047
Observational data: associations, not effects.
Original publication
Associations between MRI features and pain in first metatarsophalangeal joint osteoarthritis. Semin Arthritis Rheum. Published 18 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →