Associations between life course longitudinal growth and hip shapes at ages 60–64 years: evidence from the MRC National Survey of Health and Development
Authors' conclusion
Our analyses suggest that individual growth patterns, particularly in the adolescent period, are associated with modest variations in hip shape at 60-64 years, which are consistent with features seen in osteoarthritis.
Study context
- Population
- Individuals aged 60–64 years from the MRC National Survey of Health and Development, a nationally representative British birth cohort
- Exposure
- Height growth across childhood and adolescence vs hip shape modes HM1-10
- Outcome
- Hip shape: 10 modes of variation (HM1-10) from statistical shape models of DXA images
- Follow-up
- Ages 60-64 years
Methodological detailsnationally representative British birth cohort, Super-Imposition by Translation And Rotation (SITAR) growth curve modelling, Height measured at ages 2, 4, 6, 7, 11 and 15 years, self-reported at age 20 years
- Nationally representative British birth cohort
- SITAR growth curve modelling
- Height measured at ages 2, 4, 6, 7, 11 and 15 years, self-reported at age 20 years
Main finding
As reported in the abstract
HM6, regression coefficient
0.014
95% CI 0.08 to 0.019p<0.001
HM7, regression coefficient
0.07
95% CI 0.002 to 0.013p=0.009
HM10, regression coefficient
−0.006
95% CI −0.011 to 0.00p=0.04
HM2 (males only), regression coefficient
−0.017
95% CI −0.026 to −0.09p<0.001
Observational data: associations, not effects.
Further findings
Hip shape and SITAR height size and tempo
- Similar associations observed with greater height size and later height tempo
Hip shape and height gain in specific periods of childhood and adolescence
- Height gains during adolescence most consistently associated
Original publication
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