Association of the rs7574865 polymorphism in the signal transducer and activator of transcription 4 gene with rheumatoid arthritis in Moroccan patients
Authors' conclusion
These findings provide the first evidence from Morocco that the STAT4 rs7574865 variant may contribute to RA susceptibility.
Study context
- Population
- Moroccan patients with severe rheumatoid arthritis (RA) and healthy controls
- Participants
- 87 vs 69
- Comparison
- Patients with severe RA vs healthy controls
- RAn = 87
- Healthy controlsn = 69reference
- Outcome
- Association of STAT4 rs7574865 (G>T) with RA susceptibility
Methodological detailsGenotyping by TaqMan assays; anti-CCP2 and IgM-RF measured by ELISA
- Genotyping by TaqMan assays; anti-CCP2 and IgM-RF measured by ELISA
Main finding
As reported in the abstract
STAT4 rs7574865 genotypes and alleles
- GT genotype more frequent in patients than in controls
- T allele higher prevalence in the RA group
- Significant genotypic association with RA risk
- TT genotype absent in both groups
Observational data: associations, not effects.
Further findings
Association with demographic, clinical and serological features
- No associations with demographic or general clinical characteristics
- Significant clinical association with anti-CCP2 status
- GT genotype noticeable trend in RF-positive and anti-CCP2-negative patients vs controls; differences between serological subgroups within patients not statistically significant
Original publication
Association of the rs7574865 polymorphism in the signal transducer and activator of transcription 4 gene with rheumatoid arthritis in Moroccan patients. Clin Exp Rheumatol. Published 15 January 2026. doi:10.
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