Lupus & antiphospholipid syndrome
Association of regulatory T cells with renal outcomes in patients with proliferative lupus nephritis
Authors' conclusion
Treg cell counts are closely related to the long-term renal outcomes of patients with PLN, and increasing Treg cell levels may play an important role in improving the prognosis of the kidney, but there may be a turning point (i.e., threshold effect) at the Treg cell counts that leads to directional changes in the renal outcomes.
Study context
- Population
- Patients with biopsy-proven proliferative lupus nephritis (LN)follow-up 71.53 (53.13–97.47) months
- Participants
- 405 patients
- Exposure
- Renal endpoint vs non-renal endpoint; Treg cell level and long-term renal outcomes
- Outcome
- Renal endpoint: End-stage kidney disease (ESKD) or doubling of SCr
Methodological detailsCox regression, curve fitting and threshold effect analysis
- Cox regression
- Curve fitting and threshold effect analysis
Main finding
As reported in the abstract
Renal endpoint by Treg cell counts
Renal endpoint
10.4%
42 events
P < 0.001
- When Treg cell counts <46/μL, risk of renal endpoint decreased per 1 μL increase in Treg levels (p = 0.0029)
- 6.8%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of regulatory T cells with renal outcomes in patients with proliferative lupus nephritis. Lupus. Published 11 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →