Lupus & antiphospholipid syndrome
Association of low-grade proteinuria with changes of lupus nephritis in kidney biopsy in SLE patients
Authors' conclusion
We identified patients with proteinuria ≤500 mg/g who had lupus nephritis, with the majority ranging from Class III to V with only one class II.
Study context
- Population
- Patients with SLE with proteinuria ≤500 mg/g who underwent a kidney biopsy at Johns Hopkins
- Participants
- 27 biopsies
- Outcome
- Histopathologic findings (LN) in kidney biopsy
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
LN on kidney biopsy
- Evidence of LN
- 23 (85.1%)
- Class III
- 33%
- Class V
- 30%
- Class III/V
- 7%
- Class II
- 4%
- Class I
- 11%
Observational data: associations, not effects.
Further findings
Biopsy findings in patients with UPCR ≤200 mg/g (subgroup, n = 9)
- No signs of LN
- 22%
- Class V LN
- 44%
- Class I and III LN
- 11%
Safety
- No post-biopsy complications
- 93%
- Well tolerated
Original publication
Association of low-grade proteinuria with changes of lupus nephritis in kidney biopsy in SLE patients. Lupus. Published 21 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →