Association of hemoglobin levels with radiographic progression in patients with rheumatoid arthritis: an analysis from the BRASS registry
Authors' conclusion
Patients with low Hb levels at baseline tended to have increased radiographic progression as measured by total sharp score compared with patients with rheumatoid arthritis having normal Hb levels.
Study context
- Population
- Patients with RA in the BRASS registry
- Participants
- 1,114 patients
- Exposure
- Low vs normal baseline hemoglobin (Hb)
- Low Hbn = 224 [20%]
- Normal Hbn = 890 [80%]reference
- Outcome
- Radiographic progression (change in total sharp score) by baseline Hb
- Follow-up
- Baseline to month 120
Methodological detailsregistry analysis, prospective observational registry, descriptive analyses
- Registry analysis
- Prospective observational registry
- Descriptive analyses
Main finding
As reported in the abstract
Change in total sharp score over time · through month 120
- Larger increase in total sharp score over time with low Hb than with normal Hb
- All analyses descriptive
Observational data: associations, not effects.
Further findings
Hb over time · 10 years
- Low Hb continued to have lower Hb than normal Hb throughout 10 years, with a steady increase on average
Baseline characteristics
- Low Hb had longer disease duration, higher disease activity and more pain vs normal Hb
Effect of baseline medication
- No meaningful differences potentially attributable to medication at baseline
Original publication
Association of hemoglobin levels with radiographic progression in patients with rheumatoid arthritis: an analysis from the BRASS registry. Arthritis Res Ther. Published 27 May 2023. doi:10.
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