Endothelial protein C receptor (EPCR) deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells
Authors' conclusion
Deficiency of EPCR ameliorates arthritis in CIA via inhibition of the activation and migration of pathogenic Th cells and DCs.
Study context
- Population
- Mice with collagen-induced arthritis; T cells from RA patients and healthy controls
- Comparison
- EPCR knockout (KO) mice vs matched wild-type (WT) mice
- Outcome
- Arthritis incidence and disease severity in CIA (EPCR KO vs WT mice)
Methodological detailsanimal model (collagen-induced arthritis), EPCR gene knockout vs matched wild-type mice, in vitro studies including RA patients and healthy controls
- Animal model (collagen-induced arthritis)
- EPCR gene knockout vs matched wild-type mice
- In vitro studies including RA patients and healthy controls
Main finding
As reported in the abstract
- Arthritis incidence: EPCR KO mice >40% lower than WT mice
- Disease severity: EPCR KO mice 50% less than WT mice
Original publication
EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells. Rheumatology (Oxford). Published 25 May 2023. doi:10.
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